Total IgE
Understanding Total IgE
What is Total IgE?
A Total IgE test measures the total amount of immunoglobulin E (IgE) in the blood. This test helps diagnose conditions like certain types of infections and immune disorders. It may also be used to make guided treatment decisions in people who have allergy-associated asthma.
Immunoglobulin E (IgE) is a type of antibody produced by the immune system that helps to defend the body against potential threats or allergies. The body makes many different forms of IgE, each of which is specific to a substance that triggers an immune response. A Total IgE test measures the amount of IgE antibodies in the blood and is the sum of all the forms of IgE. However, this test does not help to identify the specific forms of IgE.
Your doctor may suggest a Total IgE test if you have symptoms of an immune disorder, a parasitic infection, or an allergic reaction from a fungal infection in your lungs. Symptoms may include abdominal pain, cough, diarrhea, dry skin, eczema, hives and swelling, shortness of breath, skin rash, etc. This test may also be prescribed if you have asthma or allergy symptoms, like itchy or watery eyes, congestion, or sneezing. For people with allergy-induced asthma, testing may help to determine the right treatment and suitable dosage.
Usually, overnight fasting is preferred for a Total IgE test. Therefore, avoid eating or drinking anything except water during the fasting period. Also, let your doctor know about any medications you might be taking as some of these medications, such as antihistamines, if taken before this test could affect your test results.
Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results will help the doctor determine your medical condition, make recommendations for lifestyle modifications such as diet and exercise, decide whether or not medication will be required to manage your condition, and formulate your overall treatment plan.
What is Total IgE used for?
A Total IgE test can be done:
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In case of symptoms of allergies.
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If a parasitic infection is suspected.
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To evaluate children with a family history of allergies.
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To evaluate in case of suspected allergic respiratory disease.
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To confirm sensitivity to foods in patients with asthma, angioedema, or skin conditions.
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To evaluate sensitivity to insect venom allergens.
What does Total IgE measure?
A Total IgE test measures the amount of IgE (immunoglobulin E) in the blood. Immunoglobulins are antibodies (proteins) produced by plasma cells (specific immune cells) when the body recognizes bacteria, viruses, other microorganisms, or any other unknown substances as harmful foreign antigens (allergy-causing substances or allergens) to the immune system.
Normally, IgE is present in very small amounts in the blood. It belongs to a class of immunoglobulins that includes five types of immunoglobulins: IgA, IgG, IgM, IgD, and IgE. The rise in the production of IgE is seen in cases of response to allergens in asthma or certain parasitic infections. Other allergens can include plant pollen, latex, pet dander, mold, eggs, peanuts, bee venom, strawberries, and other allergens substances.
Interpreting Total IgE results
Interpretations
IgE < 64.0o kUA/L
*Reference range may vary from lab to lab