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Content created by
Written by
Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
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Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Mean Corpuscular Hemoglobin Concentration

(MCHC)
You need to provide
Blood
This test is for
Male, Female

Understanding Mean Corpuscular Hemoglobin Concentration


What is Mean Corpuscular Hemoglobin Concentration?

A Mean Corpuscular Hemoglobin Concentration test helps measure the concentration of hemoglobin in the red blood cells (RBCs). This test is a key indicator to check for signs of anemia and other blood disorders. It is often done as part of a complete blood count test that also measures other types of blood cells. 

Hemoglobin is an iron-containing protein that helps carry oxygen in your body. By measuring the amount of hemoglobin in your RBCs, a Mean Corpuscular Hemoglobin Concentration test can help diagnose several medical conditions, including hemolytic anemia, thalassemia, etc. This test provides information on how effectively oxygen is being distributed throughout your body. 

Low levels of MCHC may indicate anemia or another condition that affects your red blood cells. Whereas, high levels of MCHC indicate a high concentration of hemoglobin within your RBCs. It can occur in conditions where RBCs are fragile or destroyed, or when RBCs get agglutinated (clumping of RBCs). No special preparation is required for an MCHC test; eat or drink as per your daily routine. 

Test result ranges are approximate and may differ slightly between different labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results. The results will help them determine your medical condition and formulate your overall treatment plan.

What is Mean Corpuscular Hemoglobin Concentration used for?

A Mean Corpuscular Hemoglobin Concentration test can be done:

  • As part of a complete blood count test to monitor your overall health.

  • To detect different types of anemia and other disorders related to RBCs, such as thalassemia.

  • To monitor the treatment progress for conditions such as anemia. 

What does Mean Corpuscular Hemoglobin Concentration measure?

An MCHC test measures the average amount of hemoglobin in a given volume of RBCs. MCHC is calculated by dividing the amount of hemoglobin by hematocrit (volume of blood made up of RBCs) and then multiplying it by 100. 

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Mean Corpuscular Hemoglobin Concentration


Frequently Asked Questions about Mean Corpuscular Hemoglobin Concentration

Q. Which diseases can an MCHC test detect?

An MCHC test can help detect anemia and other disorders related to RBCs, such as thalassemia.

Q. What is the benefit of getting an MCHC test done?

An MCHC test provides information about your RBCs and helps identify different types of anemia and RBC-affecting diseases.

Q. What does it mean when my MCHC levels are low?

Low MCHC levels mean your RBCs do not have enough hemoglobin (Hb). Hemoglobin is an iron-rich protein and low Hb may indicate anemia.

Q. What does it mean when my MCHC levels are high?

High MCHC levels can mean that you have a higher-than-normal concentration of hemoglobin in your red blood cells, or have conditions that cause the red blood cells to be fragile or easily destroyed. Conditions like hereditary spherocytosis, autoimmune hemolytic anemia, macrocytic anemia, severe burns, liver disease, thyroid disease, etc. may cause high MCHC levels.

Q. How is a Mean Corpuscular Hemoglobin Concentration test done?

A Mean Corpuscular Hemoglobin Concentration test is done using a sample of blood that is withdrawn from a vein in your arms. The blood sample is collected in a vial and sent to the lab for analysis.

Q. Is there any risk associated with an MCHC test?

There is no risk associated with this test. However, as a needle is used to prick and collect your blood samples, you may experience bleeding, swelling, or blood collection under your skin, which is usually self-limiting.
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