Jo-1 Antibody Serum, EIA

Jo-1 Antibody Serum, EIA test is the recommended first-line test for detecting polymyositis or inflammatory myopathies. Jo-1 antibodies are specific markers for the disease polymyositis and are seen most commonly in myositis patients who also have a severe lung disorder, interstitial lung disease (ILD). It may also be seen in patients with dermatomyositis. This test is done for evaluating patients with signs and symptoms which are consistent with a connective tissue disease, especially those patients with muscle pain and limb weakness, concomitant pulmonary (lung or respiratory) signs and symptoms, Raynaud phenomenon, and arthritis. A positive result confirms polymyositis and the possible risk of lung disease with fibrosis. A negative test for Jo-1 antibodies, however, does not exclude the diagnosis of polymyositis or dermatomyositis.