Test Detail
Understanding the Test
Test Measures
Interpreting Results
FAQ's
Other Tests
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Written by
Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
Reviewed by
Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Coagulation Profile (PT/INR & aPTT)

Coagulation Profile (PT/INR & aPTT) Includes 2 testsView All
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. A duly filled coagulation requisition form is mandatory for sample collection.
  2. Overnight fasting is preferred.
  3. A duly filled Coagulation Requisition Form (Annexure - CR/05) is preferred.

Understanding Coagulation Profile (PT/INR & aPTT)


What is Coagulation Profile (PT/INR & aPTT)?

 

Coagulation profile helps to determine the concentration of coagulation factors in the blood. It helps to assess the blood's ability to dissolve a clot as well as its clotting time. It is useful for evaluating the risk of excessive bleeding or developing clots (thrombosis).This profile includes two tests, Activated Partial Thromboplastin Time test and Prothrombin Time test.
This profile is recommended for the diagnosis of bleeding or clotting disorders, before a surgery, to patients undergoing the treatment for these diseases.
It is also suggested as a screening test before conceiving to mitigate the risk of birth defects in a baby.

 

What is Coagulation Profile (PT/INR & aPTT) used for?

Coagulation Profile is done:

  • In case of excessive unexplained bleeding

  • In case of easy bruising

  • In acute conditions such as Disseminated intravascular coagulation

  • In chronic conditions such as liver disease

  • To monitor the patients taking medicines affecting clotting ability

  • Before surgery

 

 

What does Coagulation Profile (PT/INR & aPTT) measure?

Contains 2 tests
expand icon

PT INR (Prothrombin Time)

A PT INR (Prothrombin Time) test helps to detect bleeding or clotting disorders. This test measures the time a blood sample takes to clot after chemicals are added to it. INR is a calculation that adjusts the chemicals added to the sample to measure PT and make the test results comparable among different labs.

Know more about PT INR (Prothrombin Time)

Activated Partial Thromboplastin Time

Interpreting Coagulation Profile (PT/INR & aPTT) results


Interpretations

Prothrombin time: 11 s - 15 s

Activated partial thromboplastin time: 25 s - 35 s

Reference range may vary from lab to lab*

 

Results of PT

Results of PTT

Can be seen in the following conditions

Prolonged

Normal

Diseases of liver, Vitamin K deficiency, Defective factor VII, Chronic disseminated intravascular coagulation

Normal

Prolonged

Hemophilia A or B, Factor XI deficiency, Von Willebrand disease, Factor XII deficiency, Presence of lupus anticoagulant

Prolonged

Prolonged

Defective factor I, II, V or X, Severe liver disease, Acute disseminated  intravascular coagulation

 

 

Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Coagulation Profile (PT/INR & aPTT)


Frequently Asked Questions about Coagulation Profile (PT/INR & aPTT)

Q. How is the blood sample taken?

The healthcare provider takes a blood sample from the arm. The site from where the blood is to be withdrawn is cleaned with a swab of rubbing alcohol. This is then followed by inserting a small needle which has a tube attached to it for collecting blood. Once the sufficient blood for analysis is withdrawn, the needle is removed. The site is then covered with a gauze pad.

Q. In what conditions can shortened PTT be seen?

Shortened PTT can be seen in case of disseminated intravascular coagulation, advanced stages of cancer, and acute phase reactions.

Q. What other tests can be advised by the doctor in case of abnormal coagulation profile?

In case of abnormal coagulation profile, the doctor can advise platelet count, thrombin time, fibrinogen testing, coagulation factor tests, lupus anticoagulant testing, and test for von Willebrand factor.

Q. Is there any risk associated with the withdrawal of blood sample procedure?

As such there is no risk but in few cases, bruising, bleeding, and infection at the puncture site can be seen. In very few cases, there can be swelling of the vein after the blood is withdrawn.

Q. What conditions can cause coagulation disorders?

Coagulation disorders could be due to conditions such as liver disease, thrombophilia, and hemophilia.
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