Pirfenidone

Information about Pirfenidone

Pirfenidone Uses

Pirfenidone is used in the treatment of idiopathic pulmonary fibrosis.

How Pirfenidone works

Pirfenidone is an antifibrotic medication. It works by reducing fibrosis (scarring) and swelling in the lungs. This makes breathing easier.

Common side effects of Pirfenidone

Headache, Dizziness, Insomnia (difficulty in sleeping), Loss of appetite, Weight loss, Upper respiratory tract infection, Sinus inflammation, Tiredness
CONTENT DETAILS
Written By
Dr. Love Sharma
PhD (Pharmacology), PGDPRA
Reviewed By
Dr. Shilpa Garcha
MD (Pharmacology), MBBS
Last updated
18 Feb 2020 | 11:51 AM (UTC)

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Available Medicine for Pirfenidone

FibrodoneLupin Ltd
₹256 to ₹6552 variant(s)
PirfetabZydus Cadila
₹250 to ₹6603 variant(s)
FiborespGlenmark Pharmaceuticals Ltd
₹238 to ₹6502 variant(s)
SpiropirfKoye Pharmaceuticals Pvt ltd
₹2031 variant(s)
PulmofibMSN Laboratories
₹203 to ₹6303 variant(s)
PirfenairWockhardt Ltd
₹1751 variant(s)
PirfedoCare Formulation Labs Pvt Ltd
₹203 to ₹5961 variant(s)
PirfactSun Pharmaceutical Industries Ltd
₹220 to ₹6502 variant(s)
PirfemacMacleods Pharmaceuticals Pvt Ltd
₹152 to ₹2902 variant(s)
PirfenexCipla Ltd
₹347 to ₹9004 variant(s)

Expert advice for Pirfenidone

  • Pirfenidone reduces scarring and swelling in the lungs, and helps you breathe better.
  • It is best to take this medicine with food and at the same time each day.
  • This medication may make you more sensitive to sun. Use sunscreen and wear protective clothing when outdoors.
  • Stop smoking during treatment with Pirfenidone as it can reduce the effect of the treatment.
  • It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • It may cause weight loss. Monitor your weight regularly.
  • Your doctor may check your liver function regularly. Inform your doctor if you develop abdominal pain, loss of appetite, darkened urine or yellowing of the eyes or skin (jaundice).

Frequently asked questions for Pirfenidone

Pirfenidone

Q. Is Pirfenidone a steroid?

No, Pirfenidone is not a steroid. It belongs to pyridines group of medicines. It is used to treat idiopathic pulmonary fibrosis (IPF) in adults. In IPF, the tissues of the lungs get scarred and swell with time, which creates problem in breathing. This medicine helps reduce these effects to make you breathe better.

Q. What are the side effects of Pirfenidone?

Most common side effects of Pirfenidone include skin sensitivity to sunlight, nausea, tiredness, diarrhea, indigestion or upset stomach, loss of appetite, and headache. Other common side effects include infections of the throat or the airways, bladder infections, weight loss, difficulty sleeping, dizziness, sleepiness, changes in taste, hot flushes, shortness of breath, and cough. Additionally, one may experience stomach problems such as acid reflux, vomiting, bloating, abdominal pain and discomfort, heart burn, constipation, skin problems such as itchy skin, skin redness or red skin, dry skin, skin rash, muscle pain, aching joints/joint pains, weakness, chest pain, and sunburn. It is possible that after using Pirfenidone blood tests may show increased levels of liver enzymes.

Q. What monitoring will I need during treatment with Pirfenidone?

Your doctor will check your liver function before starting treatment with Pirfenidone. This test will be repeated monthly for the first 6 months and then it will be done after every three months. In addition to that, your doctor will also monitor your lung function periodically in order to see the response to Pirfenidone.

Q. Why is it important to continue treatment with Pirfenidone?

It is important to control the progression of the disease by preserving your lung function which cannot be restored, once lost. Hence, it is highly recommended to start and continue the treatment with Pirfenidone as prescribed by your doctor. Doing so can help preserve the existing lung function.

Q. How do I know that Pirfenidone is right for me?

Only you and your doctor can decide if Pirfenidone is right for you. The doctor will only prescribe Pirfenidone after assessing your condition. Based on your response to treatment and tolerability, you should continue the medicine.

Q. If my disease is stable can I stop Pirfenidone?

Idiopathic pulmonary fibrosis is a progressive disease though its progression is unpredictable. Do not stop the medication without consulting the doctor. Continue taking Pirfenidone to slow down the progression of the disease.

Q. What should I avoid while taking Pirfenidone?

You should restrict sun exposure, while taking Pirfenidone. Wear sunblock daily and cover your arms, legs, and head to reduce exposure to sunlight. Along with that, avoid smoking as it decreases the effect of Pirfenidone.

Q. What is the survival rate of pulmonary fibrosis?

The median survival of patients with pulmonary fibrosis is 2-3 years, yet some people live much longer. The factors which can be held responsible for shortened survival are older age, smoking history, and lower body mass index. The other factors can be more severe extent of disease both radiologically and physical impairment, and the development of other lung complications or conditions.

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