Pryl 50mg Tablet SR
Prescription Required
Product introduction
Pryl 50mg Tablet SR is a tricyclic antidepressant. Different doses of this medicine help in treating and preventing different problems such as depression, neuropathic pain, and migraine.
Pryl 50mg Tablet SR is used to treat various features of depression
Pryl 50mg Tablet SR is used to treat various features of depression
Uses of Pryl Tablet SR
Benefits of Pryl Tablet SR
In Treatment of Depression
Pryl 50mg Tablet SR works by affecting the balance of certain chemicals (such as serotonin) in the brain. It helps improve mood and feelings of well-being, relieve anxiety and tension, helps you sleep better, and increase your energy level. Pryl 50mg Tablet SR is readily absorbed and starts action within approximately 6 hours of taking it orally (by mouth). It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly.
In Neuropathic pain
Pryl 50mg Tablet SR helps in relieving neuropathic pain caused by nerve damage in certain conditions. These may include painful diabetic neuropathy, post-herpetic neuralgia, or spinal cord disease. It works by affecting chemicals in the brain called neurotransmitters. By relieving pain, it helps improve your quality of life.
In Treatment of Migraine
Pryl 50mg Tablet SR helps prevent migraines by changing the way that your nerves receive pain signals. By preventing and reducing the frequency of headaches, it can help you carry out your daily activities and have a better quality of life.
Side effects of Pryl Tablet SR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pryl
- Constipation
- Dryness in mouth
- Orthostatic hypotension (sudden lowering of blood pressure on standing)
- Weight gain
- Aggressive behavior
- Nasal congestion (stuffy nose)
- Sleepiness
- Dizziness
- Headache
- Decreased libido
- Nausea
- Fatigue
- Confusion
- Tremors
- Speech disorder
- Palpitations
- Taste change
- Paresthesia (tingling or pricking sensation)
- Abnormality of voluntary movements
- Loss of accommodation
- Atrioventricular block
- Micturition disorders
- Erectile dysfunction
- Abnormal ECG
- Decreased sodium level in blood
How to use Pryl Tablet SR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Pryl 50mg Tablet SR may be taken with or without food, but it is better to take it at a fixed time.
How Pryl Tablet SR works
Pryl 50mg Tablet SR contains Amitriptyline, a tricyclic antidepressant. It has anticholinergic and sedative properties. It prevents the reuptake, and hence the inactivation of neurotransmitters called noradrenaline and serotonin, that are present at the nerve terminals in our brain. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity and helps in regulating the mood. It also stops the transmission of pain signals from nerves to the brain thereby relieving neuropathic pain (pain from damaged nerves).
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Pryl 50mg Tablet SR.
Pregnancy
CONSULT YOUR DOCTOR
Pryl 50mg Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Pryl 50mg Tablet SR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Pryl 50mg Tablet SR may cause side effects which could affect your ability to drive.
Pryl 50mg Tablet SR may impair your alertness which may affect your ability to drive.
Pryl 50mg Tablet SR may impair your alertness which may affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Pryl 50mg Tablet SR is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Pryl 50mg Tablet SR may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Pryl 50mg Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Pryl 50mg Tablet SR may be needed. Please consult your doctor.
Use of Pryl 50mg Tablet SR is not recommended in patients with severe liver disease.
Use of Pryl 50mg Tablet SR is not recommended in patients with severe liver disease.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Pryl 50mg Tablet SR
₹5.02/Tablet SR
Amitop 50mg Tablet SR
Tas Med India Pvt Ltd
₹5.17/tablet sr
3% costlier
Amitryn 50 SR Tablet
KC Laboratories
₹15.88/tablet sr
216% costlier
Ketrip 50mg Tablet SR
Kivi Labs Ltd
₹6.8/tablet sr
35% costlier
Goldep 50mg Tablet SR
Glenmark Pharmaceuticals Ltd
₹3.03/tablet sr
40% cheaper
Cutomer 50mg Tablet SR
Curis Lifecare
₹4.5/tablet sr
10% cheaper
Quick tips
- It may take 4 to 6 weeks for Pryl 50mg Tablet SR to start working. Keep taking it as prescribed.
- It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
- Avoid consuming alcohol when taking Pryl 50mg Tablet SR as it may cause excessive sleepiness.
- Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
- It may cause sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
- Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
- Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.
Fact Box
Chemical Class
Dibenzocycloheptenes Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Tricyclic antidepressants
Patient concerns
FAQs
What other lifestyle changes should I make to get maximum benefit of Pryl 50mg Tablet SR?
Antidepressants, including Pryl 50mg Tablet SR, are just one of several approaches to treat depression. Certain lifestyle changes can help you get maximum benefit of Pryl 50mg Tablet SR and help you recover fast. Keeping active and eating a healthy diet can make a significant difference to how quickly you recover from depression. Think positively and try to discuss your thoughts with others to reduce stress. Practice yoga or take up a hobby. Ensure that you have a sound sleep to calm your mind. Stay away from smoking or alcohol consumption as these will only worsen your depression. Take your medicines as prescribed even if you start feeling better.
Is there anything I need to be careful about while on therapy with Pryl 50mg Tablet SR?
Pryl 50mg Tablet SR may cause drowsiness and dizziness, especially in the beginning of the treatment. So, avoid driving or using machinery until you know how the medicine affects you. Also, it is not advisable to drink alcohol during treatment with this medicine as it might increase sleepiness.
Can the use of Pryl 50mg Tablet SR affect my sex life?
Yes, Pryl 50mg Tablet SR can affect sex life in both men and women. It may cause decreased sexual desire or you may experience discomfort during intercourse. Men may experience inability to develop or maintain an erection during sexual activity and may be unable to have an orgasm. If you notice these symptoms, do not stop taking the medicine but consult your doctor.
I have been taking Pryl 50mg Tablet SR for depression since a week and recently I have been wanting to harm myself. What should I do? Is it because of the medicine?
You should immediately consult your doctor or go to the hospital. Your suicidal tendencies may have increased because of your disease or the medicine. Generally, Pryl 50mg Tablet SR takes about 2 weeks to show its effect but may take longer. Therefore, when you start taking Pryl 50mg Tablet SR, you may have thoughts about killing or harming yourself. This is more common in people who previously had suicidal tendencies or are young adults (less than 25 years old). However, the effect of medicine is different for every individual.
Can Pryl 50mg Tablet SR cause urinary problems?
Yes, Pryl 50mg Tablet SR can cause urinary problems. It is more commonly seen in elderly patients who are more than 65 years old. The patient may face difficulty in passing urine which can further lead to a urinary tract infection. Consult your doctor immediately if you develop these symptoms.
If my pain is not relieved, can I take more than the recommended dose?
No, you should use Pryl 50mg Tablet SR strictly as prescribed by the doctor. If the dose exceeds, you may develop drowsiness, confusion, difficulty in speech, dry mouth, tiredness, difficulty in walking, fever, difficulty in breathing, blue discoloration of the skin and decreased heartbeat. Your pain may not be relieved because Pryl 50mg Tablet SR takes about 2 weeks to show its effect, but it may take longer in some cases. The duration of treatment can differ from individual to individual. Consult your doctor if your symptoms are not relieved.
Does Pryl 50mg Tablet SR cause any effect on pregnancy or the newborn?
Do not take Pryl 50mg Tablet SR during pregnancy unless recommended by the doctor. If you take this medicine during the last trimester of the pregnancy, the newborn may develop symptoms such as irritability, rigidity, irregular body movements, irregular breathing, poor drinking, loud crying, difficulty in urinating and constipation.
I have been prescribed Pryl 50mg Tablet SR for pain. When will I start feeling better?
You may start feeling better after 2 weeks of starting Pryl 50mg Tablet SR. However, it may take 4-6 weeks to see the full benefits of the medicine.
Can I stop taking Pryl 50mg Tablet SR when my pain is relieved?
No, do not stop taking Pryl 50mg Tablet SR even if the pain is relieved. You should use Pryl 50mg Tablet SR as advised by the doctor. Stopping the medicine suddenly may cause unpleasant symptoms like headache, feeling unwell, sleeplessness and irritability. Consult your doctor for the duration of the treatment since the dose of Pryl 50mg Tablet SR needs to be reduced gradually.
How long does Pryl 50mg Tablet SR take to work?
You may see an improvement in your symptoms after a couple of weeks, although it usually takes between 4 and 6 weeks before you feel the benefits. Do not stop taking Pryl 50mg Tablet SR after 1 or 2 weeks just because you feel it is not helping your symptoms. Give the medicine at least 6 weeks to work.
How will Pryl 50mg Tablet SR make me feel?
Antidepressants like Pryl 50mg Tablet SR help to gradually lift your mood. You may notice that you sleep better and are less anxious. You may worry less about little things that used to bother you. Pryl 50mg Tablet SR will not make you feel excessively or unusually happy. It will help you feel like yourself again.
Want to share the information?
Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Stahl SM, editor. Amitriptyline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 25-30.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 58-59.
- Amitriptyline. Princeton: Sandoz Inc; 2014. [Accessed on 19 Mar. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Amitriptyline. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:
Marketer details
Name: J B Chemicals and Pharmaceuticals Ltd
Address: Cnergy IT Park, 3rd floor Appa Saheb Marathe Marg, Prabhadevi, Mumbai 400025
Country of origin: India
Lab tests offered by us
Related/Popular tests
MRP
₹50.2
Inclusive of all taxes
10.0 tablet sr in 1 strip
SOLD OUT
Notify me