Kabilen 25mg Capsule belongs to a group of medicines that affect how your immune system works. $It is used in the treatment of multiple myeloma and myelodysplastic syndrome.

Kabilen 25mg Capsule is used in the treatment of many different blood and bone marrow diseases including some cancers.

Uses of Kabilen Capsule

Benefits of Kabilen Capsule

In Treatment of Multiple myeloma

If you have multiple myeloma, your body is destroying bone faster than it is being replaced. This makes bones weak and painful and more likely to break. Kabilen 25mg Capsule may be prescribed along with other cancer treatments such as chemotherapy. It is an important part of your treatment and increases the survival rate of people with multiple myeloma. This medicine will kill the cancerous cells and prevent their further growth as well as spread to other parts of the body. Follow your doctor’s instructions carefully to get the most benefit. Supplements of calcium and Vitamin D3 are also effective and may be prescribed if you do not have high blood calcium levels.

In Treatment of Myelodysplastic syndrome

Myelodysplastic Syndromes (MDS) are a group of rare blood disorders characterized by abnormal development of blood cells in the bone marrow. In MDS, the bone marrow fails to produce enough healthy and fully matured blood cells, leading to low blood cell counts, which can result in anemia, infections, and bleeding problems.

Kabilen 25mg Capsule is used to treat certain types of MDS, specifically those associated with a specific part of the chromosomes in the blood cells. It works by helping the immune system make more healthy blood cells in the bone marrow. Kabilen 25mg Capsule helps improve the production of red blood cells, reducing the need for frequent blood transfusions and making them feel better. It is important to check-up and monitor regularly to make sure it is safe and effective.

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Side effects of Kabilen Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Kabilen

Headache
Nausea
Rash
Breathlessness
Dizziness
Fatigue
Decreased white blood cell count (neutrophils)
Joint pain
Itching
Diarrhea
Low blood platelets
Peripheral edema
Cough
Back pain
Upper respiratory tract infection
Decreased appetite
Nasopharyngitis (inflammation of the throat and nasal passages)

How to use Kabilen Capsule

Take this medicine in the dose and duration as advised by your doctor. Kabilen 25mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

How Kabilen Capsule works

Kabilen 25mg Capsule is an anti-cancer medication. It works by enhancing the immune system that indirectly attacks the cancer cells. It prevents the growth of new blood vessels within the tumor. It also restricts the production of chemical messengers (cytokine and growth factor) which are responsible for the growth of cancer cells. This is how it works against cancer.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Kabilen 25mg Capsule. Please consult your doctor.

Pregnancy

UNSAFE

Kabilen 25mg Capsule is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

CONSULT YOUR DOCTOR

Kabilen 25mg Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Kabilen 25mg Capsule may cause side effects which could affect your ability to drive.
You may feel dizzy, tired, sleepy, have vertigo or blurred vision after taking Kabilen 25mg Capsule and this may affect your ability to drive.

Kidney

CAUTION

Kabilen 25mg Capsule should be used with caution in patients with kidney disease. Dose adjustment of Kabilen 25mg Capsule may be needed. Please consult your doctor.

Liver

CAUTION

Kabilen 25mg Capsule should be used with caution in patients with liver disease. Dose adjustment of Kabilen 25mg Capsule may be needed. Please consult your doctor.

What if you forget to take Kabilen Capsule?

If you miss a dose of Kabilen 25mg Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Kabilen 25mg Capsule

₹288.89/Capsule

Lenalid MF 25mg Capsule

Natco Pharma Ltd

₹616.71/capsule

113% costlier

Lenangio 25mg Capsule

Dr Reddy's Laboratories Ltd

₹275.9/capsule

4% cheaper

Celomide 25 Capsule

Celon Laboratories Ltd

₹400/capsule

38% costlier

Lenalid 25 Capsule

Natco Pharma Ltd

₹309.9/capsule

7% costlier

Lenomust 25mg Capsule

Panacea Biotec Ltd

₹600/capsule

108% costlier

View all substitutes

Quick tips

You may be monitored with regular blood tests before and during the treatment as lenalidomide may cause a fall in the white blood cells and platelets, required to fight infection, Hemoglobin and blood clotting.
Avoid activities that may cause bruising or injury and avoid contact with people who have colds or infections.
It makes your skin sensitive towards sunlight. Apply sunscreen or wear protective while going out.
It may cause dehydration. Drink plenty of water to stay hydrated while taking medication.
It is not recommended for use in children and adolescents under 18 years.
You should use proper contraceptive methods at least 4 weeks before, during and until 4 weeks after stopping treatment.
Woman of childbearing potential will be required to undergo pregnancy tests before and after the treatment.
You should inform your doctor or dentist that you are taking Kabilen 25mg Capsule before you receive any medical or dental care, emergency care, or surgery.
It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
You may be at risk of developing acute myelogenous leukemia, fatal liver problems, severe skin reactions, and fatal heart problems during treatment with Kabilen 25mg Capsule. You should discuss in advance the benefits and risks of taking this medicine.

Fact Box

Chemical Class

Phthalimide and Piperidone Derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Thalidomide & its Immunomodulatory derivatives (IMiDs)

Patient concerns

Please tell me the interpretation of the attach report, if possible. Also guide for further treatment process.

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

U r having multiple myeloma

Multiple myeloma can be cured or not

Dr. Rohan Khandelwal

Surgical Oncology

Yes, if diagnosed at the right stage

Report shows higher esr value what should i do.

Dr. Priyanka Shekhar

General Practitioner

A very high ESR usually has an obvious cause, such as a severe infection, marked by an increase in globulins, polymyalgia rheumatica or temporal arteritis. A health practitioner will typically use other follow-up tests, such as blood cultures, depending on the person's symptoms. People with multiple myeloma or Waldenstrom's macroglobulinemia (tumors that make large amounts of immunoglobulins) typically have very high ESRs even if they don't have inflammationNeed to correlate clinicallyKindly consult your doctor

FAQs

Can I take Kabilen 25mg Capsule empty stomach?

Kabilen 25mg Capsule may be taken with or without food. Always take it exactly as prescribed by your doctor. Do not crush, cut or chew the capsules. Swallow it whole with water. You should take Kabilen 25mg Capsule at about the same time on the scheduled days.

Can Kabilen 25mg Capsule be given to patients who are on dialysis?

Yes, Kabilen 25mg Capsule is given to dialysis patients after the dialysis is done. However, the doctor may adjust the dose if needed in patients undergoing.

What are the side effects of Kabilen 25mg Capsule?

Kabilen 25mg Capsule may cause side effects which include diarrhea, constipation, stomach pain, loss of appetite, weight loss, weakness, dizziness, change in ability to taste, and pain or burning of the tongue, mouth, or throat. The medicine may also cause decreased sense of touch, burning or tingling in the hands or feet, difficulty falling asleep or staying asleep, depression, and joint, muscle, bone, or back pain. You may also experience sweating, dry skin, abnormal hair growth in women, uncontrollable shaking of a part of the body, decrease in sexual desire or ability or painful, frequent, or urgent urination. Tell your doctor if any of these symptoms are severe or do not go away.

Can Kabilen 25mg Capsule cause cancer?

People with multiple myeloma (a form of cancer that begins in plasma cells, a type of white blood cell) who receive melphalan (chemotherapy) and a blood stem cell transplant with the addition of Kabilen 25mg Capsule have a higher risk of developing new cancers. These types of cancers may include certain blood cancers (acute myelogenous leukemia or AML) and a type of lymphoma called Hodgkin lymphoma. Talk to your doctor about your risk of developing new cancers if you are taking Kabilen 25mg Capsule.

Do I need to get any blood tests done while on Kabilen 25mg Capsule?

Your doctor will ask you to have a blood test before treatment and every week for the first 8 weeks of treatment. You may need to continue taking the blood tests at least every month after treatment with Kabilen 25mg Capsule ends. Frequent blood tests are important as Kabilen 25mg Capsule may decrease the blood cells that help fight infection (white blood cells) and help the blood to clot (platelets).

Do I need to use birth control methods while using Kabilen 25mg Capsule?

Women who can become pregnant must use two acceptable forms of birth control for 4 weeks before they begin taking Kabilen 25mg Capsule. Continue using contraceptives during your treatment, including the times when your doctor tells you to temporarily stop taking Kabilen 25mg Capsule, and for 4 weeks after your final dose. In men, Kabilen 25mg Capsule may pass into the semen while they are on treatment. Therefore, men must always use a latex condom every time they have sexual contact, even if they have had a vasectomy (surgery that prevents a man from causing a pregnancy). Use the contraceptive while you are taking Kabilen 25mg Capsule, during any breaks in your treatment, and for 4 weeks after your final dose.

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Related lab tests

Albumin/Globulin Ratio, Serum

Bone Marrow Smear Microscopy Examination

Calcium

Complete Blood Count

Kidney Function Test

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1742.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 784-85.
Lenalidomide. Summit, New Jersey: Celgene Corporation. [Accessed 26 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012. Lenalidomide. [Updated 2022 Aug 30]. [Accessed 08 Jul. 2023]. (online) Available from:
Lenalidomide Capsules [Package Insert]. Bangalore, India: Biocon Limited. [Accessed 08 Jul. 2023]. (online) Available from:
Lenalidomide [Prescribing Information]. Nantou City, Taiwan: Lotus Pharmaceutical Co., Ltd.; 2022. [Accessed 08 Jul. 2023]. (online) Available from:

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