Difine-OD 500 Tablet ER
Prescription Required
Product introduction
Difine-OD 500 Tablet ER is a medicine used to treat epilepsy. It helps prevent and control seizures (fits). It is also used in the prevention of migraines. Occasionally, it may also be used to treat bipolar disorder.
Difine-OD 500 Tablet ER is used to treat epileptic seizures and also for some mental behavioural disorders
Difine-OD 500 Tablet ER is used to treat epileptic seizures and also for some mental behavioural disorders
Uses of Difine Tablet ER
Benefits of Difine Tablet ER
In Treatment of Epilepsy/Seizures
Difine-OD 500 Tablet ER is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses which cause the seizures. By controlling the frequency of seizures, it will help you go about your daily activities with more confidence. It helps reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.
This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.
This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.
In Treatment of Bipolar disorder
Difine-OD 500 Tablet ER works to restore the normal balance of nerve activity in your brain. It can help prevent extreme changes in mood and help you feel less agitated. You may experience fewer episodes of low mood. It can take several weeks for this medicine to work and you may still feel low during this time. It is likely that you will take this medicine for at least six months but possibly much longer. It needs to be taken regularly to work effectively. Do not stop taking it unless your doctor advises you to. You should continue to eat well and keep fit to reduce symptoms of bipolar disorder.
In Prevention of Migraine
It is not fully established how Difine-OD 500 Tablet ER helps prevent migraines. It may change the abnormal and excessive activity of the nerve cells in the brain or increase the activity in a region of the brain associated with migraines. By preventing and reducing the frequency of headaches, it can help you carry out your daily activities and have a better quality of life.
Side effects of Difine Tablet ER
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Difine
- Decreased body temperature
- Dizziness
- Sleepiness
- Tremors
- Paresthesia (tingling or pricking sensation)
- Anemia (low number of red blood cells)
- Decreased sodium level in blood
- Liver injury
- Gastrointestinal disturbance
- Hypersensitivity
- Deafness
- Urinary incontinence
- Increase in body weight
- Pain during periods
How to use Difine Tablet ER
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Difine-OD 500 Tablet ER may be taken with or without food, but it is better to take it at a fixed time.
Safety advice
Alcohol
UNSAFE
Difine-OD 500 Tablet ER may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Difine-OD 500 Tablet ER is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Difine-OD 500 Tablet ER is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Driving
UNSAFE
Difine-OD 500 Tablet ER may cause side effects which could affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Difine-OD 500 Tablet ER is safe to use in patients with kidney disease. No dose adjustment of Difine-OD 500 Tablet ER is recommended.
Liver
UNSAFE
Difine-OD 500 Tablet ER is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips
- Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
- It can be taken with or without food, but better to take with food to avoid stoamch upset.
- Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
- Some healthy tips to prevent seizures:
- Practice yoga every day.
- Get enough sleep at nighttime.
- Limit the use of screen time such as mobile/laptop.
- Take your medication on time.
- It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
- Monitor your weight during treatment with this medicine as it can cause weight gain.
- Your doctor may get regular blood tests done to monitor how the medication is affecting your body. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
- Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Fact Box
Chemical Class
Aliphatic Carboxylic acid Derivatives
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Sodium channel modulators (AED)
Patient concerns
FAQs
What happens if I stop taking Difine-OD 500 Tablet ER?
You should not stop taking Difine-OD 500 Tablet ER without consulting your doctor. The dose of Difine-OD 500 Tablet ER should be reduced gradually and eventually can be stopped under the supervision of a doctor or specialist. Suddenly stopping the medication may lead to recurrence of symptoms or irritability, anxiety, dizziness and tremors.
Is Difine-OD 500 Tablet ER a mood stabilizer?
Yes, Difine-OD 500 Tablet ER can sometimes be used as a mood stabilizer. It is given in patients who experience rapid changes in their mood. It works by calming the hyperactivity of the brain during mood changes.
Can Difine-OD 500 Tablet ER cause weight gain?
Yes, Difine-OD 500 Tablet ER may cause weight gain. The gain in weight could be due to an increase in hunger. Keep a check on your diet and exercise regularly to prevent any weight gain. If you are have concerns related to weight gain, consult your doctor.
Does Difine-OD 500 Tablet ER make you sleepy?
Yes, Difine-OD 500 Tablet ER may make you feel sleepy. Avoid driving or other work that requires mental focus until you know how it affects you.
Does Difine-OD 500 Tablet ER cause hair loss?
Yes, Difine-OD 500 Tablet ER may cause hair loss. However, it is only for a short time and is usually dose related. Please consult your doctor if the hair loss bothers you or persists for a longer duration.
Can Difine-OD 500 Tablet ER damage my liver?
Yes, Difine-OD 500 Tablet ER can cause damage to the liver. The risk is more likely to occur during the first 6 months of starting the treatment with Difine-OD 500 Tablet ER. Symptoms of liver damage may include nausea or vomiting, loss of appetite, stomach pain, dark coloured urine, facial swelling, yellowing of the skin or white of eyes. Therefore, it is important to have liver function tests done before starting the medicine and. Tests should be done periodically during the first 6 months of therapy, especially in those who are likely to be at risk and those with a prior history of liver disease.
Can I take alcohol while I am taking Difine-OD 500 Tablet ER?
Avoid alcohol consumption while you are on treatment with Difine-OD 500 Tablet ER. Taking alcohol with this medicine may make you feel more drowsy, light headed or dizzy.
What are the laboratory tests recommended prior to taking Difine-OD 500 Tablet ER?
The doctor may suggest blood tests before starting the treatment with Difine-OD 500 Tablet ER. The tests may include blood cell count, including platelet count, bleeding time and coagulation tests These tests are also advised to avoid any spontaneous bruising or bleeding. In addition to this, liver function tests are advised before therapy. It is recommended to periodically monitor liver function during the first 6 months of therapy, primarily in those who seem most at risk and those with a prior history of liver disease.
What should be done if I start experiencing abdominal pain, nausea and anorexia?
If you experience acute severe abdominal pain along with nausea and vomiting, it may be due to pancreatitis. Immediately consult your doctor in case you experience these symptoms. Your doctor may get your levels of serum amylase checked. In case the test shows positive results for pancreatitis, the medication should be stopped immediately.
How to check for overdose of Difine-OD 500 Tablet ER?
Overdose of Difine-OD 500 Tablet ER may cause headaches, blurred eyesight due to pupils of the eyes becoming smaller, lack of reflexes, confusion and tiredness. You may also experience weak or “floppy” muscles, fits (seizures), loss of consciousness, behavioral changes and breathing difficulties such as fast breathing, shortness of breath, or chest pain. Immediate medical assistance is required in case of overdose.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
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- Divalproex sodium [Medication Guide]. Halol, Gujarat: Sun Pharmaceutical Industries Ltd.; 2022. [Accessed 20 June 2023]. (online) Available from:
- Divalproex sodium [Prescribing Information]. Ghaziabad, UP: Unichem Laboratories Ltd.; 2023. [Accessed 20 June 2023]. (online) Available from:
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Marketer details
Name: Vanprom Lifesciences Pvt Ltd
Address: GC Complex, 1st Floor, Jwala Heri Market, Paschim Vihar, New Delhi, Delhi - 110063, India
Country of origin: India
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